Polynucleotides help to stimulate fibroblast activity within the skin’s tissues. They do this by encouraging the metabolic activity of cells within the skin, increasing the rate of growth of fibroblasts, thus activating and revitalising ageing or damaged skin cells. Polynucleotides also act to prime dermal fibroblasts, producing new matrix glycosaminoglycans and stimulating the production of new collagen and elastin fibres. Polynucleotides also contain protamine sulphate which is a protein with a high arginine content. Arginine has been found to have a rejuvenating effect on the skin. When injected into the skin, polynucleotides attract the existing and future water molecules within the tissues, enabling more effective hydration. They also offer an anti-free radical effect on the skin, scavenging the damaging OH hydroxyl radicals that can accumulate as a result of internal and external stressors such as emotional stress, UV rays, smoking and pollution, all of which cause damage to the skin’s cells. 

• • Signs of skin ageing, such as lines, wrinkles, dehydration and skin laxity.
• Dark circles (polynucleotides are superb alternatives to tear trough fillers for patients who have a reaction to hyaluronic acid (HA) products)
• Hair loss and hair thinning (androgenic alopecia).
• Acne atrophic scars, surgical or trauma scars.
• UV damage, sun spots, age spots.
• Melasma.
• Rosacea.
• Stretch marks.
• Cellulite.
• Polynucleotides can also be injected prior and after some surgeries (e.g. hair transplant surgery) to accelerate the healing process. 

• Full face (including sensitive areas such as the lips and tear troughs)
• The neck.
• The Scalp.
• The upper arms.
• The décolleté.
• The thighs.
• The stomach.
• The hands.

As polynucleotides are a biological and not a synthetic substance extracted from fish, they are highly bio-compatible for use in humans and therefore offer very few if, any immunological side effects. However, as with any injectable treatment there can be some cosmetic downtime, following this treatment. These can include slight swelling, tenderness, small bumps at the injection sites and potential bruising. All of these reactions are normal and will subside in a day or so. We will advise on any aftercare that you should follow after your treatment, in your initial consultation at the clinic.

Before your treatment, a numbing cream will be used to de-sensitise the areas to be treated so the procedure should not be painful. Many patients describe the sensation as ‘stingy’ but in most cases, very tolerable.

The number of treatments required will depend on several factors:

• Your age.
• The condition of your skin.
• The severity of skin ageing.
• Your lifestyle choices.
• The kind of results you are hoping to achieve.

In general however, we recommend between two and three treatment sessions, spaced one month apart for optimum results.

Results from a treatment using polynucleotides are accumulative and can last up to 12 months. Therefore, you may wish to undergo maintenance sessions every six to 12 months.